Sentence examples for blocking its interaction with from inspiring English sources
Indeed, it has been shown that Brm interacts with Cyclin E, that Mel-18, a human homologue of Posterior Sex Combs, interacts with Cyclin D2 possibly blocking its interaction with Cdks [56], [57] and we show here that the ETP Corto interacts with CycG.
PAQR3 has been found to inhibit p110α activity by blocking its interaction with p85.
In this study, we describe the discovery of a novel series of inhibitors that targets HIV-1 NC protein by blocking its interaction with nucleic acids.
VRC01 actively binds to the HIV envelope glycoprotein gp140, blocking its interaction with CD4+ receptor on T cells and is particularly effective as it directly mimics the structure of the CD4+ receptor (Li et al. 2011).
Interfering with actin polymerization, inhibiting Arp2/3 complex, knocking down WHAMM, or blocking its interaction with Arp2/3 complex through mutagenesis all inhibit comet tail formation and reduce the size and number of autophagosomes.
Thus TGZ at 10 30 μM may affect FAK autophosphorylation by blocking its interaction with activating proteins.
This mechanism is analogous to that seen in many autoinhibited systems, where a regulatory domain binds directly to the active site of a functional domain, blocking its interactions with substrates/ligands [39].
The VEGF pathway is inhibited by soluble VEGF receptors (soluble fetal liver kinase-1 [sFlk-1]) that bind VEGF and block its interaction with endothelial cells.
Specifically, mTORC1 and S6K can phosphorylate IRS-1 to block its interaction with the p85 regulatory subunit of PI3K to negatively regulate the insulin-signaling pathway (Gual et al., 2005).
