Sentence examples for blocking its function with from inspiring English sources

Moreover, p73 activation is induced by a subset of DNA damaging drugs and blocking its function with a dominant negative mutant or siRNA led to apoptosis resistance of transformed human cell lines, irrespective of p53 status [ 61].

For instance, prevention of CXCR4 expression by using short interfering RNA technology or blocking its function with specific antibodies or synthetic peptides repressed the formation of lung metastasis, indicating that the CXCR4 ligand, SDF-1, expressed by metastatic target organs, is recruiting tumor cells via CXCR4, which is expressed on breast cancer cells [ 80- 82].

Continuous monitoring of retrotranslocation revealed that αDer1 did not block Δgpαf retrotranslocation at t0 but did block retrotranslocation after 2 min. The delay presumably resulted from αDer1 being initially unable to bind to derlin-1 or block its function when the antibodies were mixed with the RRMs.

Therefore, blocking CCR5 function with an antagonist may provide a novel treatment of cancers such as prostate cancer.

The TPR domain of CHIP apparently binds to the N-terminal region of LRRK2 indirectly via Hsp90, which is known to bind to the TPR domain of CHIP [35], because blocking Hsp90 function with geldanamycin completely prevented the binding of full-length CHIP to the N-terminal region of LRRK2.

As Dishevelled activates β-catenin signalling by disrupting GSK3β activity (MacDonald et al., 2009); we examined whether blocking GSK3β function with LiCl or SB216763 inhibited Notch signalling.

Cell culture studies comparing RHAMM−/− and wild type smooth muscle cells and blocking RHAMM function with antibodies show that RHAMM HA interactions mediate smooth muscle cell adhesion and contraction of collagen gels.

However, blocking miR-489 function with a locked nucleic acid antagomiR did not phenocopy the effects of hyperoxia, and the use of antagomiR-489 in vivo in the experimental BPD model paradoxically improved lung structure.

However, just as with mutations, if a gene has both early and late functions, blocking the early function with MOs often precludes studying the late function.

Conversely, blocking miR-1 function with antisense oligo-miR-1 in rat infarcted hearts normalized the expression of connexin 43, thus reducing arrhythmias after MI [ 100].

Blocking c-Jun function with dominant negative mutant c-Jun significantly reduced induction of MMP-1 expression in response to reduced spreading/mechanical force.