Sentence examples for blocking its function in from inspiring English sources

In addition, analysis of α6β4 in transformed keratinocytes suggests that blocking its function in early-stage tumours might in some cases be counterproductive (Ref. 46).

A long-range goal would be to improve the potency of competitors that bind to DDX3X and specifically block its function in the viral life cycle of multiple HCV genotypes.

For example, in situations where α3β1 is making a strong contribution to the maintenance of stable cell cell junctions, blocking its function might result in a more invasive phenotype rather than reduced invasion.

Trastuzumab is a humanised monoclonal antibody with specificity for the HER2 protein; it binds to the extracellular domain of HER2 and blocks its function in signal transduction.

Mutation of P833 to leucine in Vav1 blocks interaction with polyproline sequences [ 40, 56, 57], and the equivalent SH3 domain mutation in Sem5 blocks its function in C. elegans [ 58, 59].

Approximately, 1 in 3 patients with severe hemophilia A produce neutralizing antibodies (inhibitors) that block its biologic function in the clotting cascade.

Cytosolic Smac directly binds to XIAP, thereby blocking its inhibitory function on effector caspases and, in turn, allowing for their full activation.

The major objective of this review is to evaluate the known functions of Smad7, with a particular focus on its molecular mechanisms and its function in blocking multiple pathological processes in oral mucositis.

Notably, a v100 cDNA carrying a mutation that blocks its acidification function in the V-ATPase still rescued degeneration as well as the wild-type v100 cDNA.

We next analyzed this interaction by blocking Rasl11b function in Zoep mutant (As for the epistatic analysis described above, we used the oeptz57 null allele [23]).

Thus, blocking AVPR1A function in rats can actually increase social interactions, most probably by reducing social anxiety.