Sentence examples for blocking its activity in from inspiring English sources

FLT3 as well as JAK2V617F abnormity can activate tyrosine kinase and result in aberrant activation of tyrosine kinase signaling [ 34]. (3) NPmutationinn in exon 12 results in loss of its nuclear localization signal; the altered protein concentrates in the cytoplasm, where it dimerizes to wild-type NPM1, blocking its activity in the nucleus [ 43].

The A20 protein is also involved in NF κB regulation, blocking its activity, in a negative feedback mechanism [ 35].

We thus hypothesized that if GCLC contributes to this adaptation, blocking its activity in TSC2-deficient cells should perturb the redox balance.

To further confirm the involvement of VEGF in the LD model, we constructed a lentiviral vector encoding the cDNA of V65 (LV-V65) – a single-chain antibody directed against VEGF and capable of blocking its activity in different experimental paradigms.

Besides the reported associations between AVPR1B and mood or anxiety disorders [ 17- 19], evidences that the receptor has a role in behavioral traits come from the observation that blocking its activity in mice (either by gene knock-out or pharmacologically) results in decreased aggressive behaviors [ 14], reduced social interactions [ 15] and anxiolytic- and antidepressant-like effects [ 16].

A rabbit polyclonal antibody raised against L. donovani gp63 was used to block its activity in vitro (Bhowmick et al., 2008).

Peptide aptamers, molecules designed to selectively bind to a given target protein and block its activity in vivo, have been effectively used to inhibit E6 binding to its respective partners, resulting in increased p53 levels and the apoptotic elimination of HPV-positive SiHa cells [ 15].

This protein is the main target of the selective serotonin reuptake inhibitors (SSRIs), which bind SERT blocking its activity; this action allows an increase in 5-HT levels in the synaptic cleft and in serotonergic neurotransmission, being this first step for the antidepressants' long-term effect [ 2, 3].

The authors suggested that MLC-kinase acts on the cell-cell junctions and by blocking its activity the junctions remain intact, resulting in a reduced passage of leukocytes.

Bevacizumab binds to VEGF-A, blocking its biological activity, which in turn affects the vasculature that supports tumor growth [ 12, 29].

B-P4 and B-T2 successfully bound surface resident CAgp130 but were insufficient in blocking its signaling activity.