Sentence examples for blocking interaction of the from inspiring English sources

The appropriate chemokines have been shown to inhibit viral replication by blocking interaction of the gp120 envelope protein with the coreceptors.

This correlates with the "PEKN" insertion found in human DHFR, which serves as a lid over the substrate DHF site and is a major determinant blocking interaction of the current anti-folate series with human DHFR.

They bind Rho GTPases and prevent their activation by means of blocking interaction of the GTP-bound form with effectors, sequestering GDP-bound Rho proteins in the cytoplasm away from the GDP-GTP cycle, as well as by changing membrane compartment to GTPases [ 12].

This peptide has been shown to bind to CD4 and to the env glycoprotein on the virus, thus inducing the down-regulation of CD4 and CXCR4 and blocking interaction of env with the co-receptors.

To examine whether the peptides blocking interaction of recombinant TDP-43 protein with the peptide array could also inhibit TDP-43 aggregation in cells, a construct expressing a mutant TDP-43 lacking residues 187 192 [ 18] was transfected into HeLa cells.

To test whether this was the case, we developed a competition ELISA for bOPN: this assay was designed to detect any peptides that can block interaction of bOPN with the polyclonal antibody used.

Microscopic tophi may be walled off by a ring of proteins, which blocks interaction of the crystals with cells, and therefore avoids inflammation.

These mutations likely block interactions of the protein with a specific polar target.

Assuming they utilize the same protein complex as vaccinia, he says, researchers may be able to fight these infections by blocking the interaction of the two proteins.

We tested C-82, a therapeutic that inhibits canonical Wnt signaling by blocking the interaction of the protein CBP with β-Catenin and inhibiting Wnt-activated genes.

The peptide, which inhibits JAM-A/leukocyte interaction by blocking the interaction of the C2 domain of JAM-A with LFA on neutrophils and monocytes/macrophages, attenuated I/R-induced neutrophil and monocyte infiltration into brain parenchyma.