Sentence examples for blocking initiation from inspiring English sources

In this regard, it may also be useful for the adoption of selective COX2 receptor-blocking agents in prevention of oral cancer by blocking initiation, progression, or metastasis of tumors [ 20].

Consequently, any enrichment of miRNPs in sponge bodies (whose similarity with P bodies includes an almost complete lack of ribosomes [35]), would be consistent with repression blocking initiation of translation.

By supplementing existing cell cycle machinery with extrinsic cell cycle regulators, blocking initiation or progression of cancer may be possible.

For example, SIRT1 can counteract various genotoxic insults, including oxidative DNA damage, thereby blocking initiation of carcinogenesis.

These data would be compatible with a potential repressor protein binding to the RDRM and blocking initiation of transcription in standard growth conditions.

As a class, macrolides act via the same mechanism, namely, binding to the 50S subunit of the bacterial ribosome and blocking initiation of protein synthesis [ 4].

Rifampicin (final concentration 300 (µg/mL) was subsequently added and culture was continued for a further 3 h to block initiation of DNA replication [13].

However, the early steps of facial muscle specification have been shown to be independent of the presence of neural crest cells, since ablation of cranial neural crest cells in chick and amphibian embryos does not block initiation of the myogenic program in the branchial arches [21], [25] [27].

This hypothesis is supported by our observations that silencing of BECN1 to block initiation of autophagy desensitized the cells to rapamycin-induced downregulation of dNTPs.

To determine whether autophagy has a direct role in regulating the levels of dNTPs, we knocked down BECN1/BECLIN1 by expressing sh BECN1 (Fig. S7) to block initiation of the autophagy pathway.

In this study, we use Trp and FP, two highly specific drugs to block initiation or pause escape, in combination with the sensitive GRO-seq assay (Core et al., 2008) to examine the drug-induced kinetic changes in Pol II distribution over promoter proximal regions and in the gene body.