Sentence examples for blocking estrogen binding to from inspiring English sources

TAM acts by blocking estrogen binding to its receptor, while AIs block estrogen production [ 8].

By blocking estrogen binding to ER alpha (ERα), the selective ER modulator, tamoxifen remains a frontline treatment for ERα-positive breast cancer.

For breast cancer, tamoxifen (Nolvadex), which blocks estrogen binding to the estrogen receptor [39], is the standard of care following chemotherapy.

On a micro-level, though isoflavones mimic estrogen, there is also some evidence that they have anti-estrogen properties, including a role in blocking estrogen from binding to receptors (and helping them to bind in the blood instead) and inhibiting the formation of estrogen in fat tissue, according to the American Cancer Society.

TAM acts as a competitive inhibitor and prevents estrogen binding to the ER, blocking the proliferative and prosurvival effects of estrogen.

Because progesterone binding to the progesterone receptors (PRs), like estrogen binding to ERs, is growth stimulatory for breast cancer cells, using antagonists to both receptors to block tumor growth may be an attractive treatment option for ER+ and PR+ breast cancers.

These endogenous hormones are a key factor in cancer tumor formation and proliferation through a cascade starting from estrogen binding to estrogen receptor.

Two targeted therapeutic examples include aromatase inhibitors, which interfere with estrogen production, and tamoxifen, which interferes with estrogen binding to the receptor.

We have previously shown that estrogens binding to estrogen receptor (ER) α increase proliferation of Leydig tumor cells.

Therapies against ER+ breast cancers inhibit ER function either by antagonizing ligand binding to ER (tamoxifen), downregulating ER (fulvestrant) or blocking estrogen biosynthesis (aromatase inhibitors (AIs)).

It blocked estrogen hormones to prevent them from stimulating the growth of malignant cells.