Sentence examples for blocking cell cycle progression from inspiring English sources
Therefore, it was concluded that L-4 can inhibit the proliferation of EC109 cells via blocking cell cycle progression and inducing reactive oxygen species-dependent and mitochondria-mediated apoptosis.
Unphosphorylated pRb will bind and inactivate E2F factors blocking cell cycle progression and altering local chromatin [27].
In addition, TRAIL blockade results in hyperproliferation of synovial cells and lymphocytes, whereas TRAIL inhibits DNA synthesis in lymphocytes by blocking cell cycle progression [7].
These toxins, termed cyclomodulins, can promote cell proliferation or, conversely, inhibit cell growth and modulate differentiation by blocking cell cycle progression [1], [2].
As loss of several individual NMD components in tissue-culture converge at blocking cell cycle progression, this most likely reflects the activity of the NMD pathway per se and not any non-NMD functions of individual members.
PLK2 inhibits apoptosis by blocking cell cycle progression, thus maintaining genomic integrity.
The microtubule targeting compounds engage at the mitotic spindle checkpoint where they block cell cycle progression at mitosis ultimately leading to apoptosis (Bhat and Setaluri [2007]).
Checkpoint kinase 1 (ChK1) is activated in response to DNA damage, acting to temporarily block cell cycle progression and allow for DNA repair.
At the concentration that can block cell cycle progression and DNA synthesis but not elicit apoptosis, these inhibitors potentiate FasL to induce apoptosis.
The use of antimitotic substances, such as colchicine, promotes depolymerization of microtubules and prevents the formation of spindle fibers, this methodology is used to block cell cycle progression and thus induce polyploidy (Pereira et al. [2012]).
We conclude that specific cyclinE/cyclin A-CDK2 inhibitors can be developed based on the interaction between p27 and cyclin/CDK to block cell cycle progression to prevent tumor growth and survival.
