Sentence examples for blocking cell cycle arrest from inspiring English sources

The chimeric PAX3-FOXO1 fusion protein which results from a chromosomal translocation in ARMS has been implicated in blocking cell cycle arrest, preventing myogenesis from occurring.

We calculated minimal intervention sets of targets, whose inhibition might sensitize tumours by fulfilling three intervention goals: (i) blocking cell cycle arrest, (ii) blocking activation of anti-apoptotic NF-κB, and (iii) keeping at least one pathway activating 'onset of apoptosis' intact.

Interestingly, AQP3 siRNA significantly blocked cell cycle arrest induced by both nucleoside-analogs in MCF7 cells.

In response to ionizing radiation, absence of Chk2 in our model blocked cell cycle arresting phosphorylation of Cdc25C, and one of two pathways leading to degradation of Cdc25A.

It has also been proposed that RASSF1A blocks cell cycle arrest at the G1 phase through the c-Jun-NH2-kinase (JNK) pathway, as H1299 lung cancer cells stably transfected with RASSF1A showed reduced JNK and c-Jun phosphorylation, inhibition of JNK activity and down-regulation of cyclin D1 [143].

These results are consistent with previous findings showing that prolonged arrest in G2/M phase causes apoptotic cell death by blocking cell cycle progression [ 39].

In the wing margin, dpn and E spl)C could contribute to the repression of dMyc (Fig. 7C) to block cell cycle progression and arrest the cells in the G1 phase.

Cell cycle arrest is a protective cellular response understood to block cell cycle progression and to permit DNA damage repair [ 29].

Collectively, these results suggest that roscovitine has potential to block cell cycle progression of endocrine therapy-resistant cells and preferentially arrest them at the G2/M or G1 phase of cell cycle.

CifBp also blocked cell cycle progression, as demonstrated by the accumulation of G2 arrested cells containing 4N DNA content (Fig. 4B).

Gefitinib induces significant G1/S blockade in ER-positive breast cells [ 17], G0/G1 arrest together with G2/M block in pancreatic cancer cells [ 18], and block cell cycle progression at G1 phase in sensitized hepatocellular carcinoma cells [ 19].