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Instead, Morpholinos act by "steric blocking", binding to a target sequence within an RNA and simply getting in the way of molecules that might otherwise interact with the RNA.
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Also, Chordin antagonizes signaling by bone morphogenetic proteins (BMPs) by blocking binding to their receptors.
The 14-α-lipoyl andrographolide (AL-1) could directly interfere with an influenza hemagglutinin to block binding to cellular receptors in a potentially new and potent mechanism of action [ 14].
Neither RAP nor Ni(2+) blocked the binding of (125 I-alpha(2)M* to alpha(2)MSR on insulin- or buffer-treated cells, but they both blocked binding to LRP/alpha(2)MR.
Fab fragments of the anti-FcγRII mAb IV.3 were used to block binding to FcγRIIa.
In an ELISA-based competition assay, soluble 4F, but not a scrambled control peptide (scr4F), blocked binding of SR-A to known ligands acLDL and oxLDL, as well as to novel ligands apo A-I, E2, E3, and E4, while nonligands BSA and apo SAA were unaffected.
Note that a triple-NPF mutation (NPF > AAA) is required to block binding of Runt to ChiLS (B ) while a single F > A mutant Runt still binds to ChiLS (at this concentration).
To block binding of Sp1 to GC regions, we used Mithramycin A (50 nM; Sigma).
All approved carbapenems that are used clinically for the treatment of bacterial infections (imipenem, meropenem, ertapenem, doripenem, and biapenem) contain the 6-α-1 R-hydroxyethyl substituent on the β-lactam ring that sterically blocks binding to other class A β-lactamases.
Antibodies specific for RBD are expected to block binding of virus to the target cell.
In addition, Neu5Ac and galactose each displayed some ability to block binding of CTB to multiple cell lines.
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CEO of Professional Science Editing for Scientists @ prosciediting.com