Sentence examples for blocking binding of the from inspiring English sources
It is well established that sFas may bind to membrane-bound FasL, thus blocking binding of the ligand to the Fas receptor and preventing apoptosis induction in the target cell.
Antibodies specific for domain 4 of PA are capable of neutralizing toxin by blocking binding of the toxin to host cell surface receptors [10], [32], [33].
Together, these data indicate that SIL may inhibit HCV replication in part by blocking binding of the RNA polymerase to its template, but that direct inhibition of the RNA polymerase activity is unlikely to be a major contributor to its antiviral effect.
We further demonstrated that 2C5, but not 1A5, was able to block binding of the RBD to angiotensin-converting enzyme 2 (ACE2), the functional receptor on targeted cells.
Although the 15D peptide had reduced ability to block binding of the 12G5 antibody, probably because it has a negative Asp residue instead of Arg and it is known that the chemokine binding site of CXCR4 is negatively charged, the infectivity data indicate that the low-affinity interaction of 15D was still sufficient to interfere with viral infection.
Similarly, the anti-CCR8 antibody also effectively blocked binding of the CCL1-F to CCR8.
In addition to inhibiting HIV/SIV-CCR5 interactions, CCR5 inhibition would block binding of the chemokine ligands CCL3 5 to CCR5, thereby also dampening inflammatory signaling.
The ability of test sera to block binding of the MAbs to WNV antigen was compared to the blocking ability of control sera from chipmunks without antibodies to flaviviruses.
First, Oct4 could inhibit FoxD3 activation of the FoxA1 or FoxA2 promoters by blocking binding of FoxD3 to the Forkhead Box sequence in those promoters.
This allows the inhibitor to block binding of ATP to the kinase and prevents activation of the kinase [ 51].
Acetolactate synthase is a well-known target for commercial herbicides, which block binding of substrates to the active site of the ALS enzyme [ 25].
