Sentence examples for blocking autophagy at a from inspiring English sources
These CQ-loaded lysosomes can no longer fuse with autophagosomes, thus blocking autophagy at a late stage.
Adherent-invasive Escherichia coli (AIEC), are more common in people with CD, have the ability to make strong biofilms compared to non-AIEC strains correlating with high adhesion and invasion indices of neutrophils and the ability to block autophagy at the autolysosomal step, which allows for intracellular survival of the bacteria and induction of inflammation.
Consistent with the notion that IL-10 alone is insufficient for the inhibition of autophagy prompted by HIV-1, IL-10 by itself does not block autophagy at the concentrations detected in MDM cultures incubated with HIV-1 Tat.
Knockdown of the autophagic gene Atg5 using shRNA (shATG5) blocks autophagy at a proximal step by preventing the formation of the Atg5-Atg12 complex, which is required for the generation of autophagosomes [35].
Thus the inhibition of MC by blocking autophagy could be a strategy to enhance the therapeutic efficacy.
In addition, we demonstrated that cytosolic calcium is essential factor for ML-9-induced autophagy, as its removal by chelation blocks autophagy at an early stage before autophagosome formation.
46 They also suggested that blocking autophagy in tumors could be an effective treatment approach in autophagy-addicted Ras-driven cancers.
Interestingly, blocking autophagy potentiated cytotoxicity induced by rhArg, indicating that autophagy had a cytoprotective role in the treatment of rhArg.
To confirm that autophagy has a proapoptotic role in U937 cells, we reasoned that blocking autophagy by genetically silencing key proteins in the autophagic process should protect cells from vorinostat-induced cell death, similar to chemically inhibiting autophagy with CQ.
Autophagy has a self-protection role in LoVo cells exposed to DCA because enhanced apoptosis was detected by blocking autophagy when treated with DCA.
Moreover, senescent keratinocytes in culture die by autophagy, and blocking autophagy delays this process [ 21].
