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Figure 2 shows the relationship between antibody titer and transmission blocking activity in the sera.
This activity is induced by luminal nutrients and abolished by blocking activity in the enteric nervous system (ENS).
Our anti-SEC24A antibody also failed to exhibit blocking activity in the budding assay.
The use of the anti-TfRc1 antibody with blocking activity in the NS culture medium demonstrated that the aTf effects on cell proliferation in this culture system were mediated, at least in part, by TfRc1.
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It is evident from the odds ratios that the blocking activity present in the normal pregnancy is directed only against the husband's cells and not against the cells of the controls.
Likewise, during SMAdown/PHCup blocks, activity in the SMA was decreased and activity in the PHC was increased.
During SMAup/PHCdown blocks, activity in the SMA was increased and at the same time activity in the PHC was decreased (Fig. 4).
We further examined the blocking activity present in IgM and IgG fractions.
It can be observed that the odds of greatest blocking activity happen to be in the first trimester against husband's cells only.
Children with plasma antibodies that recognised GSA in the flow cytometry assay were no more likely to exhibit transmission-blocking activity in the DMFA than other children.
This is partially consistent with previous work, which has shown an association between the presence of antibodies recognising these two gamete antigens with transmission-blocking activity in the SMFA [14], [15].
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