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The drug works by blocking activation of a molecule called epidermal growth factor receptor, which causes tumor cells to grow.
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Protease inhibitors are characterized by their ability to block activation of an HIV enzyme called protease.
U0126 acts in the unique manner of blocking activation of MEK through a mechanism independent of the ATP binding site [ 12, 23].
Ddit3 heterodimerizes with C/ebp family members to form complexes that cannot bind DNA, thus blocking activation of C/ebp-driven programs, a mechanism that has been described to block differentiation in mesenchymal lineages (Han et al., 2013; Shirakawa et al., 2006).
This example was chosen specifically, as blocking activation of MAPK/JNK in response to a cellular stress using the MAPK/JNK inhibitor SP600125,,, prevents induction of autophagy in MCF-7 cells.
These data illustrate a strategy of blocking activation of adaptive autophagy pathway to improve treatment outcomes in leukemia and MCL.
On Tuesday, finance ministers from countries using the euro continued to press Slovakia to stop blocking activation of the financial safety net, or superfund.
Typical treatments for prostate cancer involve blocking activation of the androgen receptor by androgens.
This is achieved in part through blocking activation of the canonical Wnt/β-catenin signaling pathway.
These results support the hypothesis that myostatin regulates NCM growth by blocking activation of growth pathways.
Herein, we established that YopJ blocks the HOG pathway by blocking activation of the yeast MKK, Pbs2, by acetylation.
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