Sentence examples for blocking access of the from inspiring English sources

These underlie the fluctuations between the "open" and "closed" states of the lid-like NCT with respect to a hydrophilic loop 1 (HL1) on PS1, thus allowing or blocking access of the substrate peptide (EC portion) to HL1 and to the neighboring helix TM2.

DAPT would then act as an inhibitor by blocking access of the substrate to the active site.

Perhaps, the proximity of the proximal enhancer to the sna promoter gives it a 'topological advantage' in blocking access of the distal enhancer (Dunipace et al., 2011).

In the case of human DHFR, the "PEKN" insertion generates specificity by blocking access of the dihydrophthalazine to the binding site, but in Ef DHFR, the effect on a single insertion is translated to the cofactor site.

The competitive nature is in line with the structural observation that the N-SH2 domain interacts with the PTP domain, thus blocking access of the substrate to the active site.

Y701F-STAT1 is a dominant negative protein because it binds to IFN receptor SH2 domains but cannot be phosphorylated on Y701, thus blocking access of the wild-type protein to the receptor.

The fitting of serotonin into the binding pockets of MAOs demonstrates that MAOB Tyr326 would block access of the 5-hydroxy group of serotonin into the enzyme.

The size dependence of the liposome inhibition demonstrates that the liposomes physically block access of the sperm to the egg membrane thereby preventing sperm binding to all egg receptors not just the fertilinβ receptor.

This enhances ribosomal recruitment [ 1] and protects both ends of the mRNA, most likely by increasing binding of these factors to block access of the mRNA degradation machinery.

If proteins interacted for extended periods of time on chromatin, non-specific or improper binding would block access of the correct factors.

Rap instead carries a threonine (Thr61) at this position that points away from the active site, whereas in the GAP-free structure, it is in a position to block access of the Asn-thumb to the active site.