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SP-4 (residues 192 203), SP-8 (residues 483 494), and SP-10 (residues 668 679) significantly blocked the interaction between S protein and ACE2 by biotinylated enzyme-linked immunosorbent assay, with IC50 values of 4.30 ± 2.18, 6.99 ± 0.71, and 1.88 ± 0.52 nmol, respectively.
Experiments indicated that the bivalent antibody dimerized the MUC1* receptor, which activated the MAP kinase proliferation pathway, but the monovalent Fab blocked the interaction between MUC1* and its native ligand NM23.
To further investigate whether FAP-1 expression did contribute to the FasR refractory property of colon cancer cells, we blocked the interaction between FAP-1 and FasR.
Further, MP470 plus Erlotinib blocked the interaction between the PI3K p85 subunit and phosphorylated tyrosine kinases, an essential process for PI3K activation (Fig. 4C).
The results showed that a mixture of the five peptides blocked the interaction between TDP-43 and its peptide array (decrease by 76.05% ± 3.46% compared to control).
Casadevall et al. (1996) reported the presence of anti-EPO antibodies in a patient with transient PRCA, which functionally blocked the interaction between EPO and EPOR, thus resulting in impaired erythropoiesis [ 5].
Similar(49)
On other hand, water connected with COO− groups blocked the interactions between CMC chains and amylose, and the interactions among CMC chains.
To investigate the role of MDSCs in in vivo metastasis, we blocked the interactions between MDSCs and cancer cells.
After screening roughly 40,000 compounds, they zeroed in on one that seemed likely to work by blocking the interaction between the virus and NPC1.
Synthetic compounds mimicking such tetrapeptide motif effectively block the interaction between IAP and active caspases, thus triggering apoptosis.
Knowledge of structure and function of this system has allowed the development of inhibitors that block the interaction between the cytokines and their shared receptor.
More suggestions(16)
preventing the interaction between
eliminated the interaction between
prevent the interaction between
impede the interaction between
blocked the road between
blocked the association between
blocked the crosstalk between
blocked the merger between
blocked the fusion between
blocked the relationship between
blocked the contact between
blocked the binding between
blocked the highway between
blocked the line between
blocked the way between
block the interaction between
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com