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When the researchers treated the cells with molecules that blocked the function of the phosphodiesterase proteins, diseased cells responded more strongly to isoproterenol treatment, and their contraction rate and force approached that of healthy cells.
These drugs blocked the function of proteins implicated in certain stages of the HIV life-cycle [5].
Chemotaxis and haptotaxis of SMCs to various matrix proteins and PDGF were assayed using a 48-well microchemotaxis chamber in the presence or absence of antibodies that blocked the function of these integrins.
We found that blocking IFN-β from binding to its cell surface receptor had no effect on MAVS-induced apoptosis (Fig. 5B) even though the antibody efficiently blocked the function of secreted IFN-β (Fig. S5).
Although RII specific mAbs blocked F2 function more efficiently than F1, we show that a combination of F1 and F2 specific mAbs blocked the function of EBA-175 erythrocyte binding and parasite invasion in vitro, synergistically.
In addition, mutated PfI2 blocked the function of the full-length PfI2WT.
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In addition, functionalized nanoparticles themselves or their metabolites can also block the function of ABC transporters such as P-gp by direct or indirect interaction and inhibition.
Indeed, drugs that specifically block the function of the mutated EZH2 protein are in development.
Researchers gave each monkey a local anesthetic to temporarily block the function of the flexor nerves in its arm.
Consistently, blocking the function of miR-200c-3p miR-200c-3p miR-200c-3pmice from ALI, indicating miR-200c-3protectsotential therapeutic target.
Among the different ways of blocking the function of this enzyme, inhibiting its ATPase activity has been relatively less investigated.
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