Sentence examples for blocked its interaction with from inspiring English sources
Pin1 bound the NLS sequence of CRTC2 at pSer136-Pro137 and blocked its interaction with CREB.
Furthermore, we showed that human myosin IF, which has been suggested to bind to PtdIns 3,4,5) P3 in a previous proteomic study, also binds to PtdIns 3,4,5) P3 in a lipid dot-blot assay, and that mutations in the TH domain of human myosin IF blocked its interaction with PtdIns 3,4,5) PtdIns 3,4,5
Indeed, it has been shown that Brm interacts with Cyclin E, that Mel-18, a human homologue of Posterior Sex Combs, interacts with Cyclin D2 possibly blocking its interaction with Cdks [56], [57] and we show here that the ETP Corto interacts with CycG.
Interestingly, Δ300 460 mutant retained the ability to bind SPOP, analogous to TRIM28, which inhibits TRIM24 ubiquitination without blocking its interaction with SPOP (Fig. 3h).
The VEGF pathway is inhibited by soluble VEGF receptors (soluble fetal liver kinase-1 [sFlk-1]) that bind VEGF and block its interaction with endothelial cells.
In this study, we describe the discovery of a novel series of inhibitors that targets HIV-1 NC protein by blocking its interaction with nucleic acids.
The current finding suggests that Irigenin binds to the C-C loop of EDA, thereby blocking its interaction with integrins on the cell surface and thus abrogating subsequent Epithelial-Mesenchymal transition.
Interfering with actin polymerization, inhibiting Arp2/3 complex, knocking down WHAMM, or blocking its interaction with Arp2/3 complex through mutagenesis all inhibit comet tail formation and reduce the size and number of autophagosomes.
Specifically, mTORC1 and S6K can phosphorylate IRS-1 to block its interaction with the p85 regulatory subunit of PI3K to negatively regulate the insulin-signaling pathway (Gual et al., 2005).
