Exact(6)
The less restrictive single tyrosine mutant, Vangl2 (Y280A), interacted weakly with μ1-adaptin whereas mutating both tyrosine residues blocked interaction.
This study showed that the conjugation of sodium taurocholates selectively blocked interaction with antithrombin III (ATIII) while enhancing the binding with VEGF.
When the two models are used to estimate the blocked interaction force between the wheel and rail for measured wheel and rail two-dimensional roughness distributions, however, the blocked force predictions are very similar even for wavelengths that are the order of or slightly shorter than the dimensions of the contact area.
Interestingly, the P48A substitution resulted in a reduced BiFC signal while the E103R mutation blocked interaction with DmsD (Fig. 6b), suggesting that these residues, especially E103R, are important for the interaction of DmsD with the TatC subunit of the translocase.
These researchers also found that all of these MAbs specifically bound to RBD and blocked interaction between RBD and ACE2.
The Tedder laboratory mapped and characterized CD22 ligand binding domains using a panel of anti-CD22 mAbs and found that several mAbs, such as HB22.7, completely blocked interaction with its ligand on all cell types examined, while other anti-CD22 mAbs, such as HB22.27, exhibited no blocking ability [ 12].
Similar(54)
First, it has been reported that TSA blocked interactions of protein phosphatase-1 with HDACs 1 and 6; this led to increased dephosphorylation of pAkt.
The appropriate chemokines have been shown to inhibit viral replication by blocking interaction of the gp120 envelope protein with the coreceptors.
Abatacept inhibits T cell activation by binding to CD80 and CD86, thereby blocking interaction with CD28.
Binding of MYBR1 to PYL8 may block interaction with and inhibition of PP2Cs.
OPG can block osteoclastogenesis and maintain normal bone mass by binding RANKL and blocking interaction with RANK.
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