(8, 10, 39, 40) Targeting multiple key arms of the apoptotic regulatory machinery by XPO1 inhibition in MCL, including nuclear factor-κB and c-MYC in addition to p53, may not only efficiently eradicate lymphoma cells but also block emergence of p53 mutant clones.
Including a concentration of trichostatin A in the medium that had no impact on growth on its own completely blocked the emergence of colonies in the presence of miconazole, as was the case with the Hsp90 inhibitor radicicol.
Starting around the tenth century C.E., Kuran says, Islamic legal institutions slowed or blocked the emergence of central features of a modern economy.
His intention was nothing less than to overturn the European settlement agreed [to] in 1815 by the Congress of Vienna, which had reestablished an oppressive hegemony of a few great powers and blocked the emergence of smaller nations.
Despite the commission's judgment that the former republic "continues to sufficiently fulfill the political criteria for EU membership," Athens has blocked the emergence of an independent state calling itself Macedonia since the neighboring republic broke away from the Yugoslav federation two decades ago.
Wnt3a blocked the emergence of a heterogeneous Nanog expression profile from Tg2a-Nanog GFP culTg2a-Nanog GFPe-dependent manner.
First, we tested if pharmacological inhibition of KDAC function with trichostatin A blocked the emergence of azole resistance in C. albicans.
Consistently, GS at the concentration of >5 g/L blocked syncytia emergence in Molt-4 cells and HIV-1 or HIV-2 infected HUT-78 cells [ 49].
As expected, inhibition of PI3K signaling (but not p38 MAPK or MEK/ERK signaling) in isolated WDs cultured in the presence of GDNF blocked UB emergence from the WD (Fig. 3; Table 3).
Clientelism has thus come to be seen as a political "pathology," blocking the emergence of genuine democracy as well as its lasting legitimation.
