Sentence examples for blocked death from inspiring English sources
Accordingly, BJAB target cells with a blocked death receptor pathway due to the expression of dominant-negative FADD did not undergo apoptosis upon paracrine expression of TRAIL.
This mechanism had been demonstrated in studies showing that enhanced expression of antiapoptotic Bcl2 family members blocked death receptor-mediated activation of caspase 8 and downstream executioner caspases.
We used BJAB cells with a blocked death receptor signalling due to the stable expression of dominant-negative FADD (BJAB-FADD-DN).
Deletion of RIPK3 in caspase-8 deficient caspase-8 deficientresponse to that of control BMDMs, as the addition of Z-VAD blocked death in restored CreLysM Casp8fl/fl BMDMs.
Considering this altered PA homeostasis in BC tissue, a low gene expression of both SMO and APAO is in line with the tumoral blocked death-generating pathway and the high proliferating cellular rate.
cFlip is the only protein present in the mTRAIL-R DISC that is capable of blocking death receptor-mediated apoptosis.
TRAIL treatment was included as a positive control to confirm the level of caspase-8 silencing was sufficient to block death ligand/death receptor-driven apoptosis.
An interesting question raised by the authors is why blocking death results in a fixed number of undead cells, although its activation does not have equally 'precise' effects.
Since immunodeficiency virus-infected T cells die in vitro and in vivo (Li et al., 2005; Mattapallil et al., 2005), we explored macrophage recognition of this process by attempting to block death receptor-ligand interactions using published inhibitors.
As high expression of all c-FLIP isoforms is reported to block death receptor-mediated apoptosis, we followed a loss-of-function approach to determine specific functions of the different c-FLIP splice variants.
Blocking death receptor-mediated apoptosis, through depletion of caspase-8 by RNA interference, was sufficient to rescue H460 sh-BAXBAK, but not sh-NTNT cells from cisplatin, demonstrating redundancy between the two apoptotic pathways following cisplatin treatment.
