Sentence examples for blocked binding of the from inspiring English sources

Similarly, the anti-CCR8 antibody also effectively blocked binding of the CCL1-F to CCR8.

Blocked binding of the radiotracer by the nonradioactive martinostat was quantified by measuring the change in the radioactivity accumulated from time 600 s to time 3600 s, and demonstrated tracer binding was reduced dose-dependently from 86.7% to 36.5% of baseline levels by pretreatment with martinostat at 0.001 2 mg/kg.

It is well established that sFas may bind to membrane-bound FasL, thus blocking binding of the ligand to the Fas receptor and preventing apoptosis induction in the target cell.

We further demonstrated that 2C5, but not 1A5, was able to block binding of the RBD to angiotensin-converting enzyme 2 (ACE2), the functional receptor on targeted cells.

Antibodies specific for domain 4 of PA are capable of neutralizing toxin by blocking binding of the toxin to host cell surface receptors [10], [32], [33].

Although the 15D peptide had reduced ability to block binding of the 12G5 antibody, probably because it has a negative Asp residue instead of Arg and it is known that the chemokine binding site of CXCR4 is negatively charged, the infectivity data indicate that the low-affinity interaction of 15D was still sufficient to interfere with viral infection.

In addition to inhibiting HIV/SIV-CCR5 interactions, CCR5 inhibition would block binding of the chemokine ligands CCL3 5 to CCR5, thereby also dampening inflammatory signaling.

The ability of test sera to block binding of the MAbs to WNV antigen was compared to the blocking ability of control sera from chipmunks without antibodies to flaviviruses.

However, a handle region peptide, that blocked binding of prorenin to the prorenin receptor (PRR) and inhibited downstream signaling, completely prevented glomerulosclerosis and proteinuria.

In all cases free GA blocked binding of Hsp-90 to the GA beads demonstrating the specificity of the interaction (data not shown).

None of the mutations introduced into the hydrophobic pocket completely blocked binding of CR6261 or CR6323, however the 60% binding reduction measured for the neutralisation escape mutation H111L (HA2) suggests that incomplete blocking could still be functionally relevant (Fig. 9a).