This is of relevance, as direct blockage of cell cycle in OPCs would invariably result in cell differentiation (Dugas, Ibrahim, & Barres, 2007).
This defect is due to a blockage of the initiation of endocrine cell differentiation.
Blockage of cell cycling at later stages of mitosis did not affect appressoria formation, suggesting that the checkpoint regulating cellular differentiation operates at the G2-M boundary [ 50].
Activation of cell cycle checkpoints after DNA damages leads to the blockage of cell cycle progression.
Inappropriate expansion of hematopoietic progenitor cells is primarily caused by a blockage of cell maturation.
Our findings suggested that the normal NHERF1 function in mammary epithelial cells involves blockage of cell cycle progression.
Programmed death ligand 1 (PD-L1) is involved in the blockage of cell cycle in T-cells [ 31].
In plants exposed to Al, this mechanism activates blockage of cell cycle progression and thus root growth.
Leukemia is preceded by a dramatic expansion of cells resembling hematopoietic stem cells and lymphoid-committed progenitors prior to disease onset, accompanied by a blockage in B-cell differentiation at the early pro-B stage.
Interestingly, loss of Fbw7 is frequently found in T-cell acute leukemia (T-ALL), a disease caused by the blockage of proper differentiation from progenitor cells to mature T cells.
