On the other hand, blockage of NG2 has been shown to facilitate the growth of ascending sensory axons across the caudal boundary of a lesion [ 217].
Blockage of VEGF-A has been shown to reduce vascular permeability.
A blockage of starch synthesis has been shown to increase the accumulation of lipids in several starchless mutants of microalgae [ 30, 67].
First, the MMN depends on intact NMDA receptor signalling: pharmacological blockage of NMDA receptors has been shown to significantly reduce the MMN, both in invasive recordings studies in monkeys (Javitt et al., 1996) and human EEG/MEG studies (Kreitschmann-Andermahr et al., 2001; Umbricht et al., 2000, 2002).
Blockage of the Hedgehog pathway has been shown to decrease survival and proliferation of cancer cells in cholangiocarcinoma cell lines [ 90].
Although many patients take drugs like statins and blood pressure medicine to reduce their risk of stroke, surgical treatment of severe blockages in the carotid artery has been shown to be more effective than medical therapy alone in preventing ischemic strokes caused by a buildup of plaque in the arteries.
Inhibition of this cell population though blockage of SDF-1/CXCR4-mediated migration has been shown to attenuate bleomycin-induced lung injury in mice [ 9].
Recently, it has been shown that following blockage of electrical activity, GluRδ2 is expressed not only on spines but also in excitatory postsynaptic assemblies in the smooth surface of PC proximal dendrites [35].
On the single synapse level, it has been shown recently that global blockage of activity also leads to a decreased ability of synapses to maintain their size [47].
Particularly in CRC, specificity of PHD inhibitors is warranted because PHD2 inhibition has been shown to increase tumor growth and PHD3 blockage has been associated with a reduced apoptotic response to irradiation (Chan et al, 2009; Xie et al, 2012).
