Sentence examples for blockade the expression of from inspiring English sources

Upon TNF blockade, the expression of BMP7 was increased in the articular cartilage of affected joints, whereas in the synovium the expression levels of BMP2, BMP7, and GDF5 were unchanged, suggesting that at least part of the regulation of BMP expression is TNF-independent.

To evaluate the effect of Sp1 blockade on the expression of extracellular matrix genes, clones of NIH 3T3 fibroblasts stably transfected with an anti-sense Sp1 expression vector.

These data suggest that blockade of the expression of STAT3-drived cell growth and apoptosis-related genes may be involved in the inhibition of STAT3 decoy ODN on growth of human lung cancer cells in culture.

PD-L1 blockade significantly increased the expression of TNF-α, IL-6 and decreased the level of IL-10 in CLP murine plasma.

Similarly, S1P2 and S1P3 blockade or knockdown altered the expression of RGS4 and TXNIP (data not shown).

We further demonstrated that Ihh blockade by cyclopamine inhibits the expression of type X and MMP-13 in human cartilage organ cultures.

To control for changes in T-cell subset composition of the analyzed blood samples following fludrocortisone administration in vivo, effects of the MR agonist (and its specific blockade by spironolactone) on the expression of these molecules were examined in additional in vitro experiments.

In breast cancer cell lines, blockade of Notch pathway repressed the expression of Snail and Slug and decreased acquisition of mesenchymal features under hypoxia conditions [ 46].

Taken together, these findings show that TNF-α blockade has paradoxical effects on the expression of Th17-related cytokines in animal models of autoimmune diseases.

Recent studies also found that blockade of STAT3 activity by the expression of the dominant-negative STAT3 can inhibit growth of AGS gastric cancer cell line, thus further suggesting that JAK/STAT may play an important role in development of gastric cancer (Kanai et al, 2003).

It was, therefore, decided to investigate whether treatment based on TNF blockade in rheumatoid arthritis (RA) affects the expression of synovial HMGB1.