Sentence examples for blockade of this pathway from inspiring English sources

Blockade of this pathway reversed primary pulmonary hypertension and improved survival.

In this review, we highlight the role of the TWEAK/Fn14 pathway in mediating key pathologic processes underlying LN involving both glomerular and tubular injury, and thus the potential for renal protection via blockade of this pathway.

Blockade of this pathway represents a novel therapeutic approach for treatment of sickle disease.

On the other hand, adequate pharmacological blockade of this pathway following short-term in vivo treatment with an anti-GITRL antibody is effective at protecting from disease development.

In the case of erythroid differentiation, activation of PI3K/AKT is not merely an association, since blockade of this pathway inhibits differentiation [26], [27], [28].

Both genotypes showed a downward trend in the Stat1 response to IFNα as the mice aged, but the lpr mice showed an almost complete blockade of this pathway in all cell types starting at 10 weeks of age (Fig. 3A).

Therefore, since all regulators of the Akt pathway upstream of mTORC1 appear activated, it suggests that the blockade of the pathway occurs downstream of this complex.

Furthermore, the blockade of this inhibitory pathway is particularly promising, since PD-1 blockade seems to be well tolerated in cancer immunotherapy trials.

Blockade of the pathway at multiple levels overcomes resistance, and inhibitors are in clinical development.

We thus analyzed whether the blockade of the pathway downstream of β1-ADR by PKI 14-22 a selective PKA inhibitor impairs social learning and recognition.

In cultured cells, treatment with L is more effective than T in achieving this inhibition, and the additive effect of the L + T combination achieves a more powerful blockade of the pathway than either therapy in isolation.