These focused on QT prolongation and blockade of the ion channel (Kv11.1) encoded by the human ether-a-go-go-related gene (hERG).
Our second hypothesis was that sevoflurane produced vasorelaxation in part via the blockade of calcium ion channels.
Some residues revealed a possible blockade of both ion flux through the channel and the selectivity filter.
Cell type-specific pharmacology for activating genetically engineered ion channels has been described (Slimko et al., 2002; Magnus et al., 2011), and here we demonstrate rapid cell type-specific blockade of a native ion channel with a small molecule.
The blockade of this cascade is believed to attenuate signs of physical opiate withdrawal.
Blockade of this pathway reversed primary pulmonary hypertension and improved survival.
The direct blockade of this step has long been recognized as most attractive for therapeutic intervention.
According to these findings, we believe that blockade of this enzyme may be essential for preventing the disease.
Blockade of this pathway represents a novel therapeutic approach for treatment of sickle disease.
Furthermore, the blockade of this inhibitory pathway is particularly promising, since PD-1 blockade seems to be well tolerated in cancer immunotherapy trials.
