Sentence examples for blockade of this interaction from inspiring English sources

It has also been demonstrated that the LFA-1→ICAM-1 interacanon can increase T-cell cytotoxicity by causing mobilisation of cytotoxic granules, whilst antibody blockade of this interaction causes a reduction in cytotoxicity (Zhou et al, 1998).

CD4 is an important accessory and costimulatory molecule that augments the signal received by the TCR complex and helps in the activation of the T cells 45. Blockade of this interaction using anti-CD4 antibodies increases the threshold of activation through the TCR, so that, under these conditions, only cells with high affinity have the capacity to be activated and proliferate 46.

The main underlying mechanism for this is blockade of the interaction of phosphodiesterase (PDE) type 4D with the cardiac β2AR, which is normally mediated by the actions of GRK2 and βarrs on the receptor.

Without such controls, at the completion of this replicate, a conclusion that the mechanism is via blockade of the interaction of CD47 with SIRPa, (as in title) is not possible.

These findings suggest that ICOS is involved in abnormal T cell activation in SLE, and that blockade of the interaction between ICOS and its receptor may have therapeutic value in the treatment of this intractable disease.

Our data suggest that ICOS plays an important role in the immunopathogenesis of SLE and support the possibility that blockade of the interaction between ICOS and B7RP-1 may have therapeutic value in treating this intractable autoimmune disorder.

The inhibition of T-cell activation involves the blockade of the interaction between T-lymphocytes and antigen presenting cells by binding to an adhesion molecule involved in this process, LFA-1 [5].

It is largely thought that the benefit derives from blockade of the interaction between VEGF and its receptor VEGFR2 on endothelial cells, which mediates key functions in angiogenesis and vascular function [2].

These effects may be abolished by a blockade of the interaction of FAP-1 with FasR.

The protective effects of anti-HMGB1 mAb might be explained by its blockade of the interaction between HMGB1 and RAGE, a key mechanism in the initiation of inflammatory and oxidative responses.

The reduction in hydrolysis ability may be caused by the blockade of the interaction between the enzyme and the substrate, resulting from the alkylation of the Cys residue at the subsite by a cystein protease inhibitor.