Sentence examples for blockade of this channel from inspiring English sources

Blockade of this channel would reduce DCT/CNT Na+ reabsorption (mimicking EAST/SESAME syndrome) [ 26], predisposing to increased downstream ENaC-mediated Na+ absorption electrically coupled to increased K+ secretion through apical ROMK channels.

The blockade of this channel by a selective small molecule inhibitor (TRAM-34) was first shown to have immunosuppressive effects on T lymphocytes (Wulff et al., 2000) and further tested on T cell-mediated diseases such as inflammatory bowel disease, experimental autoimmune encephalomyelitis, rheumatoid arthritis, and asthma (reviewed in Lam and Wulff [2011]).

Neurons expressing this SA mechanically gated current are believed to be involved in mechanonociception, as blockade of the channel responsible for this current by the conotoxin NMB‐1 increases mechanical pain thresholds, without affecting light touch or heat sensitivity.

Both genetic knockout and pharmacological blockade of this ion channel was shown to be neuroprotective in EAE-induced mouse spinal cord tissue [ 99].

While French farmers lifted their blockade of the Channel tunnel yesterday, the British transport minister, Lord Macdonald, criticised protesting British farmers and lorry drivers who yesterday targeted an oil refinery and a motorway.

In the case of YnaI channel, different binding affinities of disparate anions to the ion selective filter (SMC) due to chemical interactions (Fig. 4A and Table S1), leads to different degree blockade of the channel gating.

In symmetrical K+, this treatment reduced the open probability at +60 mV (membrane potential) by 94±10% (n = 5), also indicating a blockade of the channel by astemizole.

The structural similarity between the neurotoxins is a property that enables effective blockade of the channel.

However, the channel functions only when the cell membrane is depolarized due to the blockade of the channel by the magnesium [II] ion (Mg2+).

One possible mechanism for resurgent current involves the blockade of the channel pore by the C-terminus of β4 subunit of sodium channels (Grieco et al., 2005; Bant and Raman, 2010).

Nevertheless, we found that the blockade of these channels with TEA also inhibited vasorelaxation, but that this occurred only in higher concentration.