Sentence examples for blockade of the interaction from inspiring English sources

The observed blockade of the interaction between cancer cells and fibronectin was not due to B49Mod1 blocking fibronectin since B49Mod1 does not block adhesion of shCTL or shBST-2 cancer cells to fibronectin-coated B49Mod1-treated plate (Fig. 3C).

The inhibition of T-cell activation involves the blockade of the interaction between T-lymphocytes and antigen presenting cells by binding to an adhesion molecule involved in this process, LFA-1 [5].

It is largely thought that the benefit derives from blockade of the interaction between VEGF and its receptor VEGFR2 on endothelial cells, which mediates key functions in angiogenesis and vascular function [2].

These effects may be abolished by a blockade of the interaction of FAP-1 with FasR.

Without such controls, at the completion of this replicate, a conclusion that the mechanism is via blockade of the interaction of CD47 with SIRPa, (as in title) is not possible.

The reduction in hydrolysis ability may be caused by the blockade of the interaction between the enzyme and the substrate, resulting from the alkylation of the Cys residue at the subsite by a cystein protease inhibitor.

CD4 is an important accessory and costimulatory molecule that augments the signal received by the TCR complex and helps in the activation of the T cells 45. Blockade of this interaction using anti-CD4 antibodies increases the threshold of activation through the TCR, so that, under these conditions, only cells with high affinity have the capacity to be activated and proliferate 46.

In a murine model of experimental allergic conjunctivitis, in vivo stimulation of OX40 with an anti-OX40 antibody led to the exacerbation of ocular surface inflammatory disease, while antibody blockade of the OX40/OX40L interaction inhibited disease expression [20].

Conversely, in the particular case of autoimmunity, while GITR activation appears counterproductive, no reagents were available until recently to assess whether effective blockade of the GITR/GITRL interaction could inhibit lymphocyte autoreactivity and prevent autoimmunity.

This suggests that blockade of the GITR GITRL interaction may be a novel immune-based therapy in stroke.

When VEGFR2 is expressed, it becomes the dominant receptor driving VEGF-induced chemotaxis and specific blockade of the VEGF VEGFR2 interaction is sufficient to inhibit chemotaxis [ 9, 23].