Sentence examples for blockade of key from inspiring English sources

Moreover, our findings with Mf-1 suggest that the mechanism for inappropriate TSH secretion in patients with RTH is likely due to blockade of key histone modifications normally induced by thyroid hormone on the TSHα subunit promoter.

These results suggest that cervical cancer patients might benefit from the therapeutic blockade of key signaling events that regulate the crosstalk between endothelial cells and tumor cells.

The favorable clinical benefits obtained with inhibitors of tumor necrosis factor (TNF -α) and inTNF -αkin (IL)-1 suggest thandthe blockade of key interleukiny cytokIL -1has been the IL -1tant isuggest thatdevelopmenthef new therapeutic applications [ 2].

Among the best-known is disruptive action, like mass demonstrations and the blockading of key transit routes.

Moreover, being an inhibitor of de novo purine biosynthesis (because of the blockade of the key enzyme GARFT), pemetrexed was shown to increase the expression of dCK as a compensatory mechanism [ 22].

In both regulatory states, elevated levels of miR-17-92 miR-17-92 miR-17-92stimulate clusterolinerAMLon and survival capacity by a post-transcriptional blockade of the key factors required for mayloid differentiation, apoptostimulateell-celle arrest.

The pharmacological blockade of ROCK, a key signaling component for myelin-associated growth inhibitors, reduced axonal U-turns and potentiated AAV2.Stat3-ca-induced regeneration.

We and others have shown that blockade of formation or action of key immune inhibitory mediators such as prostaglandin E2 (using COX-2 inhibitors) (Jassar et al, 2005) or blocking TGF- β (using kinase inhibitors or blocking antibodies) (Kim et al, 2008; Wallace et al, 2008; Llopiz et al, 2009) are effective in enhancing immunotherapy.

We identified recurrently mutated genes that showed positive association with cytolytic activity, including beta-2-microglobulin (B2M), HLA-A, -B and -C and Caspase 8 (CASP8), highlighting loss of antigen presentation and blockade of extrinsic apoptosis as key strategies of resistance to cytolytic activity.

Other interventionist activities include blockades, economic boycotts, and assassinations of key officials.

These findings demonstrate that Met-F-AEA induced cell cycle blockade relies on modulated expression and activity of key S phase regulatory proteins.