Sentence examples for blockade of growth from inspiring English sources
Our results suggest that a therapeutic strategy to inhibit the upstream stimulus for PI-3Kinase through blockade of growth factor receptors may provide a workable alternative.
These trials are working on the premise that complete ER blockade combined with effective signal transduction blockade of growth factor pathways may abrogate resistance mechanisms and provide greater control of cancer cells.
In all four cell lines, the blockade of growth was associated with substantial reductions in ER protein expression with resultant decreased transcriptional activity, as evidenced by decreased PgR mRNA and cyclin D1 protein expression levels.
Indeed, this is supported by our finding that fulvestrant treatment enhanced the ability of HRGβ1 to stimulate signalling via ErbB3 and ErbB4, resulting in this ligand's potently overriding the suppression of cyclin D1 protein expression and the blockade of growth by fulvestrant in all four cell lines.
Next, we investigated the effect of IS3 blockade on growth of primary CML cells isolated from patient samples.
We next tested the effects of IS3 blockade on growth of BaF3 wild-type and IM-resistant BCR-ABL1 mutant cells.
We then examined the effect of IGF1 blockade on growth of 4T1.2 mammary tumours in vivo.
Similar effects of AP-1 blockade on growth suppression have been shown in one out of four breast cancer cell lines and in a colon cancer cell line (Ludes-Meyers et al, 2001; Suto et al, 2004).
In recent years, strategies have been developed to enhance and repair thymic function through androgen blockade, administration of growth and differentiation factors, and transplantation of stem cell-derived thymic epithelial cells (Hollander et al., 2010; Lai et al., 2011).
Moreover, studies using chronically hypoxic SU5416-treated rats indicated that increased apoptosis of ECs created conditions favoring the emergence of apoptosis-resistant cells and that blockade of ECs growth factors receptors worsen the pathological vascular remodeling [ 14].
This suggests that blockade of multiple growth factor and receptor pathways may be needed to increase the efficacy of cancer therapy.
