Sentence examples for blockade of cell surface from inspiring English sources

We further analyzed whether blockade of cell surface GRP78 influenced the secretion of MMP-2 and MMP-9 by examining the level of MMP-2 and MMP-9 in the conditioned medium.

We found that treatment with the N-20 antibody significantly decreased MMP-2 content in the condition medium, indicating that blockade of cell surface GRP78 inhibited the secretion of MMP-2 in hepatocellular carcinoma cells).

Using cell adhesion assay, we found that blockade of cell surface GRP78 with the NTD antibody decreased the binding ability of tumor cells to fibronectin in QGY-7703 cells (Fig.  1h).

We further found that blockade of cell surface GRP78 using the antibody against the NH2 terminal domain of GRP78 inhibited the phosphorylation of Src at Y416 and FAK at Y397.

For example, ligation of cell surface GRP78 with α2M* promotes the proliferation of cancer cells in prostate cancer cells, blockade of cell surface GRP78 using the antibody against the COOH-terminal domain of GRP78 reverted the pro-proliferative effect of α2M* [ 10, 11, 35, 36].

Blockade of cell-surface TGF-β with neutralizing antibodies, with soluble TGF-β receptor, or with recombinant latency-associated peptide disrupts the ability of these cells to block responder T cell proliferation, confirming TGF-β as an instrument of suppression [ 6- 8, 12, 13, 15, 29].

In NCCIT cells, blockade of Cripto binding to cell surface GRP78 using the antibody against the NH2-terminal domain inhibited tumor cell proliferation, suggesting that the NH2-terminal domain of cell surface GRP78 also plays a pro-proliferative role in NCCIT cells [ 26].

Finally, immunohistochemistry showed the presence of cytosolic and nuclear β-catenin and nuclear Cyclin D1, markers consistent with preserved Wnt/β-catenin signaling despite constitutive blockade of the cell surface receipt of Wnt signaling ligand.

Blockade of the cell surface GRP78 in Mahlavu and SMMC7721 cells inhibited the activity and secretion of MMP-2.

The blockade of this latter cell surface glycoprotein deregulates vesicle uptake by tubular cells [ 24].

These data suggested that blockade of the endogenous cell surface GRP78 inhibited EMT.