Sentence examples for blockade of cell death from inspiring English sources
In addition, Brandt and collaborators demonstrated that effective neuroprotection (blockade of cell death) after SE did not prevent the development of SRS in adul rats.
It is unclear why we did not observe a complete correlation between binding to ubiquitinated RIP1 and blockade of cell death.
Harmol, a beta carotenoid, induced death of lung cancer cells A549 was associated with increased expression of LC3 [ 45] and siRNA knockdown of LC3 resulted in blockade of cell death, which, in turn, served to prove that harmol-induced autophagy was only a death mechanism [ 45].
XIAP is the most potent endogenous caspase inhibitor (Stennicke et al, 2002) and its overexpression results in a blockade of cell death arising from a number of different triggers including cytotoxic drugs, ionising radiation and growth factor deprivation (Holcik and Korneluk, 2001; Holcik et al, 2001).
The effect of NF-κB blockade on cell death was minimal at 4 hours of TNF treatment and it became more discernable at 8 and 24 hours.
The decrease in viable cell number in RTX or GA101-treated MALC observed in Figure 2C might reflect either a cell-cycle blockade or induction of cell death.
Similarly, LC3-GFP puncta were seen in cells treated with BKM120, but not with etoposide, demonstrating the specificity of autophagy induction to PI3K pathway blockade rather than to a generalized induction of cell death.
Our data thus yield new insights into the mechanism of cell death induced by transcriptional blockade.
A recent report has implicated activated stress inducible JNK in a cell culture model of HD [19] and its pharmacological blockade resulted in a statistically significant but partial inhibition of cell death [19].
Therefore, we investigated alternative mechanisms of cell death or survival in response to PI3K/mTOR blockade in resistant cells, such as autophagy.
Blockade of NF-κB/p65 binding to DNA with helenalin correlated with induction of cell death in a dose-dependent manner [ 14].
