Sentence examples for blockade mode from inspiring English sources

Whether these antibodies utilize the same blockade mode as pembrolizumab or avelumab remains undetermined.

By an uncompetitive mechanism or an open-channel blockade mode of action, GYKI 52466 or BDZ- f would inhibit the open-channel state only.

Indeed, these two inhibitors share a common binding mode (blockade of basic exosite I of the proteinase and parallel alignment of N-terminal residues across the active-site cleft).

Thus, CTLA-4 blockade provides a mode of Treg modulation.

Treaty No-Blockade: Similar to the forty-minute treaty mode, but no blockades are permitted.

This suggests that IFNγ blockade potentially represents an effective mode of intervention in lethal septic shock.

There was also inhibition of spontaneous TRPC5 current, again suggesting that blockade was independent of the mode of activation of TRPC5.

These challenges have now prompted promising clinical trials on combination therapies with multiple anti-HER agents and development of new therapies with alternative modes of HER2 blockade [ 4, 7, 8].

Their primary mode of action is the blockade of prostaglandin synthesis by cyclooxygenases (COX): Constitutively expressed COX-1 is involved in fundamental mechanisms of homeostasis, whereas the inducible COX-2 mediates inflammation.

Current Hsp90 inhibitors are categorized into several classes based on distinct modes of inhibition, including (i) blockade of ATP binding, (ii) disruption of co-chaperone/Hsp90 interactions, (iii) antagonism of client/Hsp90 associations and (iv) interference with post-translational modifications of Hsp90.

The precise mode of action of therapeutic TNF blockade is not clear, and several mechanisms have been suggested.