Sentence examples for blockade mechanism from inspiring English sources

By analyzing the results, active site architecture, certain key residues and pharmacophore common-features that are responsible for substrate specificity were identified on the Kv1.5 potassium channel, which would be very helpful in understanding the blockade mechanism of Kv1.5 potassium channel and providing insights into rational design of novel Kv1.5 blockers.

At large the blockade mechanism becomes inefficient.

This assumption may be well justified in our example, which concerns neutral atom quantum computing, where the Rydberg blockade mechanism is used for two-qubit quantum gates [7, 8]. Figure 1 Concatenation of gates carried out in parallel on different qubits (a), and in serial on the same qubits (b) in a quantum computer.

The nature of the "blockade" mechanism is not clear, nor has the Na-dependent Cl−/HCO3− exchanger been isolated and cloned to date.

The dynamical mechanism of HFS-induced suppression of neuronal firing revealed below is relevant in the context of the depolarization blockade mechanism (Beurrier et al. 2001) as well as neural jamming (Benabid 2003; Benabid et al. 2005).

In contrast, it is reported that XIAP can further bind to the substrate-binding cleft of active caspase-3, via its N-terminal linker, hence, providing a steric blockade mechanism for substrate binding.

van Rossum, J. M. The significance of dopamine-receptor blockade for the mechanism of action of neuroleptic drugs.

However, gene deletion may not completely recapitulate the effects of channel blockade, as compensatory mechanism may counterbalance the function of the absent gene-protein.

Two new anti-obesity drugs, rimonabant (Acomplia®, Sanofi-Aventis) and taranabant (Merck), work by a new mechanism: blockade of the cannabinoid 1 (CB1) receptor, an integral part of the endocannabinoid system (ECS) [15].

Likewise, acceleration from an initial slow rate was also reported to facilitate early after-depolarization in canine myocardial M cells and Purkinje fibres under hERG blockade via a mechanism involving intracellular calcium loading (Burashnikov and Antzelevitch, 1998).

It is conceivable that as VEGFR blockade persists, the mechanisms contributing to resistance become more diverse.