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VEGF pathway blockade is an effective treatment for patients with advanced RCC.
IL-1 blockade is an effective and safe treatment in MWS patients.
In this regard, we have previously shown that mineralocorticoid receptor blockade is an effective intervention to prevent renal injury induced by I/R (Mejia-Vilet et al, 2007; Ramirez et al, 2009).
Michenfelder and colleagues [ 29], Rodriguez and colleagues [ 30], and Zwischenberger and colleagues [ 31] demonstrated that the suppression of shivering by neuromuscular blockade is an effective method for diminishing VO2.
Data from animal models suggest that IFN-γ is the key cytokine involved in this inflammatory cascade and IFN-γ blockade is an effective treatment for HLH in mice [ 45].
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To determine whether chronic β-blockade is an effective therapy in preventing ventricular arrhythmias for RTT, we chronically treated male Mecp2 Null/Y mice and wild-type control animals with propranolol (10 mg/kg body weight), or placebo, administered via an osmotic pump for 28 days.
Interruption of chemokine-GAG interactions, even in the absence of chemokine-receptor blockade, is a highly effective approach to reduction of allograft rejection, reducing vascular inflammation and prolonging allograft survival.
In ER-positive breast cancer, hormonal blockade with tamoxifen is an effective treatment for early and advanced disease.
Since TNFα is involved in the induction and maintenance of many inflammatory diseases and blockade of TNFα is an effective treatment for these conditions, TACE/ADAM17 has been considered a therapeutic target.
Pharmacological blockade of cholesterol absorption is an effective strategy for LDL-lowering.
It is widely known that TNF plays important roles in the pathogenesis of RA and blockade of this cytokine is an effective therapy for RA [ 33].
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