Sentence examples for blockade has been demonstrated from inspiring English sources
In this mouse model of ALS glutamatergic excitotoxicity through altered expression of glutamate transporters and protection by glutamate receptor blockade has been demonstrated, similar to studies in the EAE model for multiple sclerosis [29], [30], [31], [32].
Whilst VEGF blockade has been demonstrated to efficiently reduce neovascularization progression and leakage in age-related macular degeneration, its exact place in the management of DR remains to be clarified.
Usefulness of the TRPV1 blockade has been demonstrated to be beneficial in pain induced by Herpes zoster, diabetic peripheral neuropathy, bone cancer, arthritis, inflammatory bowel disease and migraine [36], [37], [38], [39], [40].
Effective ET-1 blockade has been demonstrated in SLE patients with pulmonary arterial hypertension.
The opioid upregulation effect of temporary naltrexone or naloxone blockade has been demonstrated multiple times previously [ 41, 42].
Preclinical proof-of-concept for PD-1/PD-L1 blockade has been demonstrated by many studies: improvements in various antitumor T-cell functions have been observed.
Variations in the management of sedation, analgesia, and neuromuscular blockade have been demonstrated internationally [ 2, 8- 12].
The mechanistic rationale of targeting cytokine pathways central to the pathogenesis of RA, but without the immunosuppressive side effects of several of the TNFα blockade biologics, has been demonstrated in the successful use of tocilizumab to treat RA [ 15].
Consistent with the high degree of aldosterone excess demonstrable in patients with resistant hypertension, blockade of aldosterone has been demonstrated to provide particular benefit to RH [ 5].
Similar induction of Oli-neu differentiation through the blockade of ROCK has been demonstrated previously [ 22, 23].
CCR5 blockade, for example, has been demonstrated to enhance proliferation of xenografts from breast cancer cells bearing WT p53, and the presence of Δ32 polymorphism has been associated with higher risk of relapse in breast cancer patients with p53 WT tumours (Manes et al, 2003).
