Sentence examples for blockade approach from inspiring English sources

Inhibition of NMDA receptors blocks LTP and LTD induction, although recent studies using pharmacological NMDA receptor subtype blockade approach has proposed that LTP induction is specifically dependent on activation of NR2A-containing receptors and LTD requires activation of NR2B-containg receptors [39], [40].

Our trial strategy is thus similar to the total androgen blockade approach to prostate cancer where this approach has been successful.

We used a "glucocorticoid blockade" approach as previously reported (40), by combining a GR antagonist (RU38486, mifepristone) with a cortisol biosynthesis inhibitor (metyrapone).

It has been advocated that the dual blockade approach of ACE inhibitors and ARBs theoretically should result in improved outcomes in both cardiovascular disease and chronic kidney disease which are usually associated with bone disturbances [ 41].

In this respect, the recent positive results of EMBLEM [ 34], a short-term phase II epratuzumab (anti-CD22) trial performed in patients with lupus without severe renal/central nervous system involvement, further stress the potential value of a B-cell blockade approach in lupus.

Despite promising preclinical data, translation of CD40/154 blockade approaches has proved difficult due to the expression of CD154 on platelets, which causes risk of thromboembolic events.

1– 3 Although there have been recent encouraging therapeutic approaches using pathway and checkpoint blockade approaches and some indication of prolongation of survival, in many centers, the typical treatment options for disseminated disease still remain seriously limited in their ability to induce long-term survival.

International activists have tried in the past to break the naval blockade by approaching Gaza by sea.

Given the recent disappointing clinical trial results with targeted B-cell depletion and co-stimulatory blockade, targeting approaches based on biomarker-defined subsets of disease is an attractive future direction.

Injection of anesthetics into nerves in the chest wall, called nerve blockade, is another approach to pain management; this does not depress respiration the way some pain medications can.

More research is also needed to evaluate the efficacy of BTLA blockade as an approach to improve the host response to infection in vulnerable populations.