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The TMA block was constructed using a Manual Tissue Arrayer 1 (Beecher Instruments, Silver Spring, MD, USA) with a 1.0-mm diameter core biopsy needle.
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The effectiveness of the PMCM lower bound is demonstrated by examples, where pipelined shift-and-add multiple constant multiplication blocks are constructed using the algorithms from [7, 8, 22, 30] and [36] for the case of 2-input additions and the algorithm from [10] for the case of 3-input additions.
Linkage disequilibrium (LD) between marker loci was assessed and haplotype blocks were constructed using Haploview 4.1.
Haplotype blocks were constructed using the LD block parameters [73], and the D' confidence interval algorithm in the Haploview program.
Briefly, tissue blocks were constructed using archival formalin-fixed, paraffin-embedded radical prostatectomy specimens from the 82 patients with pathological state of pT3a or b and pre-operative PSA stage of >3.
Haplotype blocks were constructed using the default block search algorithm of Gabriel et al.[ 18].
Tissue microarray blocks were constructed using an automated tissue microarrayer (TMA Master, 3DHistech, Budapest, Hungary).
Tissue blocks were constructed using a tissue array (Minicore; Alphelys Impasse Paul Langevin, Plaisir, France).
TMA blocks were constructed using the TMA-builder from Histopathology Ltd. (AH-diagnostics, Denmark).
Haplotype blocks were constructed using the LD-based empirical block definition proposed by Gabriel, et al. [ 44].
Linkage disequilibrium was assessed and haplotype blocks were constructed using the four-gamete rule option in HaploView v4.2.
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