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The level of sensory block was assessed using the pinprick test (1 = hypoalgesia; 2 = analgesia; 3 = analgesia plus hypoesthesia; and 4 = anesthesia) using a 22 G blunt hypodermal needle.
When the peak sensory block was determined, the degree of motor block was assessed using a modified Bromage Scale (in which 0 = no paralysis; 1 = unable to raise extended leg; 2 = unable to flex knee; 3 = unable to flex ankle) [ 16].
The level of motor block was assessed using the modified Bromage scale (0 = no motor block, able to flex hips, knees and ankles; 1 = just able to flex knees, unable to extend legs; 2 = able to move ankles, unable to flex knees; 3 = unable to flex ankles, knees or hips, complete motor block).
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Diversity of chemical structures for the styryl molecules and for their chemical building blocks was assessed using Cactvs bit strings which represent chemical structures as 881- dimensional binary sequences.
Linkage disequilibrium (LD) and haplotype blocks were assessed using the Haploview programme (http://www.broad.mit.edu/mpg/haploview/) applying default parameters according to Gabriel et al [34].
Whole chromosome comparisons of larger orthologous blocks were assessed using the Cinteny server [ 42] and Roundup database [ 43].
Preliminary analyses revealed that d-prime values for block 8 and all subsequent blocks violated normality, thus analysis of the effects of task and stimulus pair type across the first 7 blocks were assessed using a 3 (task: novel-AV, verbal-AV, shape-AV) × 7 (block: 1, 2, 3, 4, 5, 6, 7) repeated measures ANOVA.
The level of interobserver agreement upon validity of scoring and deletion status per represented block of tumour was assessed using Kappa statistical analysis.
The joint significance of each block of added covariates was assessed using adjusted Wald tests.
Sensory block of the shoulder was assessed using loss of sensation to pin prick 30 min after injection if possible without compromising operating room (OR) logistics.
Change in caloric intake was assessed using the Block Food Frequency Questionnaire (Block FFQ).
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