Sentence examples for block viability from inspiring English sources

However, NAC was neither able to block viability nor protect mitochondria from the loss of MMP, suggesting that the protective effect of α-tocopherol could be largely attributed to the mitochondrial membrane stabilisation and that ROS generation is of minor importance and likely to be a consequence of the loss of MMP.

We also found that ERK1/2 phosphorylation decreased after the PD98059 treatment, and blocked osteoblast viability and ALP activity.

In contrast, depsipeptide lacked this specificity and blocked the viability of HBECs with similar or greater potency than of lung cancer cells.

In the case of depsipeptide, one such activity may be its ability to lower global levels of histone methylation as we observed at concentrations that blocked the viability of cancer cells.

We further provide evidence that miR-149, miR-326, miR-148b and miR-520a-3p miR-520a-3p miR-520a-3pility of MCF7 cells and thus possess tumor suppressive properties.

To explore whether the function of HDACs was modulated by inhibitors at concentrations that block cancer cell viability, we performed enzyme activity assays in purified systems and in cell extracts.

The most effective compound 36 inhibits Aurora kinases in vitro in the nanomolar range and diminishes HCT 116 cell viability blocking cytokinesis and inducing apoptosis.

New protein translation is important in maintaining neutrophil functional viability: blocking either translation or transcription increases the rate of neutrophil apoptosis [15], [16].

TSA inhibited HDAC activity in purified systems in vitro, while depsipeptide's inhibition of HDACs at doses that blocked cancer cell viability required components of cell extracts.

When EPCR was suppressed by siRNA or blocking antibody cell viability, cell invasion and cartilage degradation were reduced by more than 30%.

In addition, at concentrations that blocked cancer cell viability, TSA effectively inhibited purified recombinant HDACs 1, 2 and 5 and moderately inhibited HDAC8, while depsipeptide did not inhibit the activity of purified HDACs in vitro but did in cellular extracts, suggesting a potentially indirect action of this drug.