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The full block traces shown in Figure 4C for both the hiPSC-CM models and the hAdultV-CM model are illustrative of the I NaCa block occurring 10 beats after blocker administration: traces at the steady-state were not considered because of reduced intracellular ion concentrations.
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In c and d, we show the events scatter plots of ΔI block and dwell times of the free and P.a.-blocked α-HL corresponding to the representative traces shown in a and b.
The traces shown in a are indicated with the same colour in b.
(B1b and B2b) Expanded calcium traces shown in B1a and B1b.
(A1b and A2b) Expanded calcium traces shown in A1a and A2a.
The example traces shown in Figures 9 and 10 were obtained from the same preparation, which was slightly susceptible to PdN6 disconnection; it exhibited 5 VSI bursts per swim episode with PdN6 intact and 4 bursts after PdN6 was blocked.
All traces within the black boxes were used to generate traces shown in Figure 6A D.
(B ) Phase-plane plot from the traces shown in (A ).
Right: dV/dt of sample traces shown in the left.
(C ) dV/dt corresponding to traces shown in (A ).
The packet trace shown in Figure6 is generated with 524,288 samples per buffer; the sampling time for each block is 524,288/25 Msps = 21 ms, this result corresponds with Figure6.
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