Sentence examples for block the processing of from inspiring English sources

For example, an A/G SNP that is located at the 24-nucleotide downstream of the 3' end of the mature miR126, can significantly block the processing of pri-miR126 to mature miRNA in the RS4 11 cells (Harnprasopwat et al. 2010).

It is likely that α1-PDX can block the processing of other proteins implicated in the invasive potential of tumor cells, such as growth factors and adhesion molecules, as previously reported in vitro and in vivo models [22], [23], [25], [38].

Finally, recent studies have shown that LIN-28 may recognize the pre-let-7 loop nucleotides and block the processing of human pri-let-7 RNAs into mature miRNAs in embryonic stem cells, suggesting that pre-miRNA loops may be recognized by LIN-28 or LIN-28-like RNA binding factors that control mature miRNA biogenesis [23] [25].

In addition to nucleic-acid based strategies (i.e., anti-miRs and miRNA sponges), small chemical molecules able to block the processing of the pre-miRNAs by Dicer are also envisaged [ 149].

Furthermore, a G/U polymorphism (rs12975333), located at the eighth nucleotide within the mature sequence of miR-125a, has been functionally characterized to block the processing of pri-miRNA into pre-miRNA and alter the translation suppression on the lin-28 target mRNA [87], [88].

However, we did observe that Inhibitors of both β and γ-secretases blocked the processing of SMP30, with the former showing maximum effect (Figure 7D).

Even though inhibitors to both β and γ-secretases blocked the processing of SMP30, disparate compartmentalization of SMP30 and secretases preclude us to suggest that secretases are directly responsible for the processing of SMP30.

Mutation of the presumptive catalytic serine in Osw3 blocks the processing of Osw3 pro-domain and results in increased spore wall permeability, suggesting that proteolytic activity of Osw3 is necessary for proper assembly of the outer layers of the spore wall.

Taken together, these reports support our findings that TRAIL-mediated upregulation of c-FLIPS blocked the processing of caspase-8 at DISC and promoted survival of NSCLC cells.

Apart from this alpha-1 antitrypsin blocks the processing of group antigens (Gag) and envelop proteins (Env), which results in suppression of HIV-1 morphogenesis [ 63].

Thus, the polymerase of an upstream gene may transcribe into the downstream neighbour, interfering with the neighbour's transcription (e.g., by blocking the processing of transcription termination, or by direct collision with another polymerase transcribing the downstream gene).