Sentence examples for block the processing from inspiring English sources

For example, an A/G SNP that is located at the 24-nucleotide downstream of the 3' end of the mature miR126, can significantly block the processing of pri-miR126 to mature miRNA in the RS4 11 cells (Harnprasopwat et al. 2010).

It is likely that α1-PDX can block the processing of other proteins implicated in the invasive potential of tumor cells, such as growth factors and adhesion molecules, as previously reported in vitro and in vivo models [22], [23], [25], [38].

Finally, recent studies have shown that LIN-28 may recognize the pre-let-7 loop nucleotides and block the processing of human pri-let-7 RNAs into mature miRNAs in embryonic stem cells, suggesting that pre-miRNA loops may be recognized by LIN-28 or LIN-28-like RNA binding factors that control mature miRNA biogenesis [23] [25].

Recently, we have demonstrated that cells infected with C. pneumoniae [33] and C. trachomatis resist TNF-induced apoptosis primarily by the up-regulation of cIAP-2 and the stabilization of IAP-IAP complexes to block the processing and activation of effector caspases [25].

In addition to nucleic-acid based strategies (i.e., anti-miRs and miRNA sponges), small chemical molecules able to block the processing of the pre-miRNAs by Dicer are also envisaged [ 149].

Furthermore, a G/U polymorphism (rs12975333), located at the eighth nucleotide within the mature sequence of miR-125a, has been functionally characterized to block the processing of pri-miRNA into pre-miRNA and alter the translation suppression on the lin-28 target mRNA [87], [88].

Diamide oxidation also blocked the processing for pGPfs-1C C67A/C95A although this was less pronounced than that seen for the pGPfs-1C plasmid encoding a cysteine containing protease.

However, we did observe that Inhibitors of both β and γ-secretases blocked the processing of SMP30, with the former showing maximum effect (Figure 7D).

Even though inhibitors to both β and γ-secretases blocked the processing of SMP30, disparate compartmentalization of SMP30 and secretases preclude us to suggest that secretases are directly responsible for the processing of SMP30.

Taken together, these reports support our findings that TRAIL-mediated upregulation of c-FLIPS blocked the processing of caspase-8 at DISC and promoted survival of NSCLC cells.

Thus, the polymerase of an upstream gene may transcribe into the downstream neighbour, interfering with the neighbour's transcription (e.g., by blocking the processing of transcription termination, or by direct collision with another polymerase transcribing the downstream gene).