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In this study, we used phage display peptide libraries to identify peptides antagonists that block the interactions between hCXCL8 and hCXCR1/2.
Consistently, NdpA (L21E) lost the ability to block the interactions between ERK2 with MEK1 (Fig. S4F).
One may block the interactions between cancer cells with their surrounding environment to halt or slow an invasive process.
Recently, Sakai et al. suggested the mechanism that NK4 did not directly block the interactions between VEGF and the receptors, but rather indirectly suppressed the VEGF-mediated angiogenic environments through impairing fibronectin assembly [ 22].
A more thorough understanding of the complex mechanisms of SS might also lead to pharmacological strategies to inhibit or block the interactions between chemokines and chemokine receptors or to disrupt the cytokine network as a means to inhibit the initiation and/or progression of the disease.
Treatment of the cells with arginine-glycine-aspartic acid (RGD) peptides that block the interactions between integrins, in particular α5β1, and their ligands (Hynes, 2002), almost completely prevented the adhesion of ASM-treated tumor cells to fibronectin-coated cover slips (Fig 5D).
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Synthetic compounds mimicking such tetrapeptide motif effectively block the interaction between IAP and active caspases, thus triggering apoptosis.
Knowledge of structure and function of this system has allowed the development of inhibitors that block the interaction between the cytokines and their shared receptor.
Rationally designed CD80 and CD154-binding peptides block the interaction between cell surface costimulatory molecules on antigen-presenting cells (APCs) and T cells.
Accordingly, several PD-1/PD-L1 blockers have been designed to block the interaction between PD-1 and PD-L1 to enable anti-tumour immunity.
Several chemicals, such as Nutlin and MI-219, have been developed to block the interaction between Mdm2 and p53 (Shangary et al., 2008; Vassilev et al., 2004).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com