Sentence examples for block the interaction with from inspiring English sources

The BCL-2 family binders block the interaction with their natural interaction partner and will be valuable reagents to test the apoptotic response in functional assays.

It might bind to the PAM2 domain and block the interaction with a complete PAB protein.

Using an isotype control, therefore, does not yield an interpretable result unless the isotype antibody binds to the same target cell (optimally CD47) with similar affinity, but does not block the interaction with SIRPa.

In principle, the introduction of the bulky ADP-ribose moiety could sterically block the interaction with a binding partner, create a new docking site for ADP-ribose binding domains in other proteins, or induce a conformational change.

Epithelial cells, grown in 96-well plates, were incubated for 30 min with 100  μL/well of DMEM-F12 only or supplemented with fibronectin (1  μg/well), antibodies anti-integrin α5 β1 that block the interaction with RGD site in fibronectin (Abcam) or anti-integrin α5 (Santa Cruz Biotechnology).

Furthermore, heparin completely blocked the interaction with LPS as well as antimicrobial activity, confirming that heparin interacting sequences of PrP mediate LPS binding, and thus, antimicrobial activity (not shown).

The CD28 aptamers described in this work could be used to modulate the immune response either blocking the interaction with B7 or enhancing vaccine-induced immune responses in cancer immunotherapy.

Natalizumab is a monoclonal antibody against α4-integrin, blocking the interaction with its ligands.

It does so by binding to their shared p40 subunit, therefore blocking the interaction with their cognate receptors.

Bad phosphorylation causes inactivation of its pro-apoptotic properties by blocking the interaction with Bcl-XL, [ 44, 51].

At the same time, cripto binding to activin blocks the interaction with ActR-IB and subsequently prevents the ligand-mediated association of ActR-IB with ActRII/IIB [ 65].