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Synthetic compounds mimicking such tetrapeptide motif effectively block the interaction between IAP and active caspases, thus triggering apoptosis.
Rationally designed CD80 and CD154-binding peptides block the interaction between cell surface costimulatory molecules on antigen-presenting cells (APCs) and T cells.
Knowledge of structure and function of this system has allowed the development of inhibitors that block the interaction between the cytokines and their shared receptor.
"One of the exciting things about these findings is that, if we can block the interaction between tau and the nuclear pore, it might allow existing neurons to become more functional in patients, so one of our next steps will be determining whether or not that is possible," said Hyman, who is director of the Mass General-based Massachusetts Alzheimer's Disease Research Center.
Accordingly, several PD-1/PD-L1 blockers have been designed to block the interaction between PD-1 and PD-L1 to enable anti-tumour immunity.
Several chemicals, such as Nutlin and MI-219, have been developed to block the interaction between Mdm2 and p53 (Shangary et al., 2008; Vassilev et al., 2004).
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In this study, we used phage display peptide libraries to identify peptides antagonists that block the interactions between hCXCL8 and hCXCR1/2.
Consistently, NdpA (L21E) lost the ability to block the interactions between ERK2 with MEK1 (Fig. S4F).
One may block the interactions between cancer cells with their surrounding environment to halt or slow an invasive process.
Recently, Sakai et al. suggested the mechanism that NK4 did not directly block the interactions between VEGF and the receptors, but rather indirectly suppressed the VEGF-mediated angiogenic environments through impairing fibronectin assembly [ 22].
After screening roughly 40,000 compounds, they zeroed in on one that seemed likely to work by blocking the interaction between the virus and NPC1.
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