Sentence examples for block the initial step from inspiring English sources
Activation of these receptors may inhibit opening of mPTP, which can block the initial step of intrinsic apoptosis [ 41- 44].
To determine if exosomes block the initial steps in the JAK-STAT pathway we looked at STAT1 phosphorylation following IFN-γ stimulation.
Unlike reagents that block the initial steps of EMT (Boyer et al., 1999; Mercado-Pimentel et al., 2007), antibody treatment showed normal endothelial cell separation on the cell surface (Fig. 3C).
Among the approaches towards disease modifying treatment of Alzheimer's disease blocking the initial step of the amyloid cascade, Aβ42 generation, has received most attention.
6 Celecoxib is a well-known nonsteroidal anti-inflammatory drug (NSAID) that specifically inhibits COX-2 by blocking the initial step of prostaglandin synthesis.
This resin can only bind modified phosphopeptides since cysteine was blocked during the initial step.
Thus, developing probes for Aβ species imaging could be used for early diagnosis of AD, and blocking the initial steps of Aβ aggregation with small molecules has emerged as a valid disease-modifying therapy for Aβ.
The initial step involves the detection of the verified block listed nodes among the mobile nodes in MANET.
When these cells are grown at the non-permissive temperature, the initial step in the protein-ubiquitylation cascade is blocked leading to a dramatic reduction in the levels of ubiquitylated proteins compared to control cells grown at 35°C.
Internalization further prevents the toxin from interacting with mAbs, which can therefore only act efficiently during the initial step, i.e. when the toxin is free, by blocking toxin binding to its receptors.
