Hence, parasite repression of DUSP1 could block the induction of arginase, a known mediator of killing of H. polygyrus in the mouse32.
To confirm the role of NF-kB in 13-HPODE-induced MCP-1 expression and to selectively block the induction of such inflammatory genes in VSMC, we designed novel molecular approaches to knockdown NF-kB with short interfering RNAs (siRNAs).
High levels of NAbs block the induction of IFN-β-inducible markers, including Myxovirus Resistance Protein A (encoded by the MX1 gene), resulting in a loss of bioactivity and therapeutic benefit.
Mutations in the NPR1 gene completely block the induction of SAR by signals such as salicylic acid (SA).
Here, we have inserted two glycans into the dominant site for tier-1 NAbs, the gp120 V3 region, to block the induction of off-target antibodies.
We also show that an E2F RNA ligand can block the induction of S phase in quiescent cells stimulated by serum addition.
AP5 is known to block the induction of Schaffer-collateral-CA1 LTP [19], [20].
Consistent with this notion, cycloheximide did not block the induction of LTP in synaptosome.
Of particular note, we show for the first time that JNK inhibition could effectively block the induction of Atg7 upon drug exposure of cells.
Notably, nifedipine did not block the induction of phospho CREB by 8CPT (Figure 8E), also in agreement with the proposed pathway.
As PD184352 reduced, but did not block, the induction of pri-miR-125a we were able to test the ability of IKKβ inhibitors to inhibit pri-miR-125a transcription when ERK1/2 activation was blocked by PD184352.
